Three mice groups were employed with varying degree of hepatic microvesicular steatosis: a wildtype (WT) mice group with no microvesicular steatosis, a transgenic mice group with constitutive overexpression of uridine phosphorylase (UPase-TG) that exhibited mild microvesicular steatosis, and a wildtype mice group fed with 400 mg/kg/day of fenofibrate for 5 days (WT+fenofibrate) that exhibited severe microvesicular steatosis. Here, UPP1 is linked to steatosis.