The fact that three different somatic mutations in LMX1A have been found in gliomas of the CNS (COSMIC,http://www.sanger.ac.uk/perl/genetics/CGP/cosmic? action = gene&ln = LMX1A) may shed light on potential (postnatal) functions of LMX1A in the human CNS on top of the well-researched role of this gene in midbrain and the development of dopaminergic neurons [47]. This evidence concerns the gene LMX1A and glioma.