PTGS2 and malignant colon neoplasm: As an example, the RNA-binding protein CUGBP2 interacts directly with specific AREs within the first 60 nucleotides of the COX-2 3′-UTR and that binding stabilizes the COX-2 mRNA yet inhibits its translation [27]; tristetrapolin binds to COX-2 3′UTR and decrease mRNA levels in colon cancer [28], whereas Human Antigen R (HuR) is a translational enhancer of COX-2 in ovarian carcinoma [29] and in colon carcinogenesis [20].