Of notice, study patients demonstrating high tumor PI3K-mediated signaling activity, as all array substrates of this specific pathway (PIK3R1, CTTN1, PLCG1, PDPK1, and RASA1) were highly phosphorylated, had particularly poor metastasis-free survival after radical treatment of the pelvic cavity. The gene discussed is RASA1; the disease is neoplasm.