However, it is important to keep in mind that such huge expansions in SCA7 (>200 residues), which have been described in only very few cases, induce pathologies that can no longer be classified as SCA, the disease, manifest from the first weeks post-pregnancy onward, affecting several non-neuronal tissues, such as the heart, kidneys and liver, and causing early lethality during the very first years of life [53]–[56]. This evidence concerns the gene ATXN7 and autosomal dominant cerebellar ataxia.