Sayed et al demonstrated that miR-1 inhibits cardiac hypertrophy by affecting the growth-related targets, including Ras GTPase-activating protein (RasGAP), cyclin-dependent kinase 9 (Cdk9), fibronectin, and Ras homolog enriched in brain (Rheb) [10]. Here, RASA2 is linked to cardiac hypertrophy.