MLH1 and colorectal carcinoma: As shown in Table 2, the MLH1 -93G>A polymorphism was significantly associated with increased risk of CRC in two genetic models: AG versus GG (OR = 1.06, 95% CI = 1.01–1.11), and AA/AG versus GG (OR = 1.06, 95% CI = 1.01–1.11, Figure 2A) (each study weighting for each study was from 4.1% to 54.2%).