CPZ and cancer: The list of overlapping genes revealed 4 genes of WNT signalling pathway, which were downregulated with age amongst them AXIN2, a gene that modulates both amplitude and duration of active Wnt/β-catenin signalling pathway – mutations or loss of AXIN2 have been associated with cancer and disturbance in the development of dentition [36], FZD7 which acts as receptor for Wnt proteins and has been involved in carcinogenesis [37], CPZ – a metallocarboxypeptidase [38] and WIF1, a secreted Wnt antagonist.