In male skin biopsies significantly up-regulated Kegg pathways were f.e. the arginine and proline metabolism (4), insulin signalling (5) and acute myeloid leucemia (5), whereas downregulated were melanogenesis (6), gap junction (4), ubiquitin-mediated proteolysis (4), basal cell carcinoma (3) and WNT signalling pathway (5) (Table 1). The gene discussed is INS; the disease is basal cell carcinoma.