These functional associations of IGF2 and KCNQ1 rely on publications reporting how a differentially methylated region in KCNQ1 controls imprinted expression of other genes in the neighborhood [17] and about epigenetic abnormalities in the IGF2/H19 region of Beckwith-Wiedemann syndrome patients [18]. This evidence concerns the gene H19 and Beckwith-Wiedemann syndrome.