Recently, genome-wide association studies have suggested that a nonsynonymous sequence variation (rs738409 C>G) that results in an isoleucine to methionine substitution at residue 148 (I148M) in PNPLA3, contributes to differences in hepatic lipid content and the susceptibility to NAFLD [7], [15], [16]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.