PNPLA3 and metabolic dysfunction-associated steatotic liver disease: However, the contribution of PNPLA3 rs738409 genotypes to NAFLD susceptibility in the Han Chinese population is controversial, one study with a group of 112 NAFLD patients showed that the PNPLA3 rs738409 polymorphism was not associated with steatosis [21], while another study with a group of 203 NAFLD patients found that the PNPLA3 rs738409 polymorphism was associated with steatosis [22].