The absence of detectable disease-associated prion protein (PrPSc) in human vCJD dental tissues [12] is not incompatible with the levels of infectivity observed in this study, given that the bioassay model is considered to be 100–1000 fold more sensitive than even the high sensitivity Western Blot model used in the cited study. Here, PRNP is linked to variant Creutzfeldt-Jakob disease.