Included in this group are the cryopyrin-associated periodic syndromes (CAPS) that are caused by autosomal dominant mutations in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene, also called NLRP3 or NALP3 (NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3). Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.