While most of the microRNAs were upregulated in the LS tissue, only two microRNAs, mir29c and mir103-2, were significantly downregulated (Fig. S7B), and these have been shown to be involved in tissue fibrosis surrounding a cardiac infarct [26], and in the modulation of IGF-1 mediated stabilization of mRNA [27], respectively. Here, IGF1 is linked to infarction.