As inflammasome mediated IL-1β production may be involved in causing tissue stress and damage in a number of prevalent human diseases, including Type II diabetes, obesity, and coronary artery disease [49], the understanding of the regulation of the homeostatic pathways that can limit tissue stress and damage and restore tissue homeostasis, may lead to novel treatment strategies that can limit inflammation induced tissue stress and damage, and become a viable option to protect tissue undergoing cytokine induced damage. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.