Additionally, we show through the use of MEK and PI3K specific inhibitors, that tumor suppressive miR-15 and let-7 family members miR-195, let-7c, let-7g, and miR-98 are under the regulation of both MAPK and PI3K/AKT signaling, while miR-15b is solely regulated by MAPK signaling. This evidence concerns the gene AKT1 and neoplasm.