Instead, mutually exclusive mutations in GNAQ and GNA11 (genes encoding small GTPases, which usually mediate signals from G-coupled receptors) that lead to the constitutive activation of several downstream signaling pathways including the MAPK-pathway have been implicated in the pathogenesis of the majority (greater than 80%) of uveal melanomas [31], [32]. This evidence concerns the gene GNA11 and uveal melanoma.