Tumor stromal pathways are also in evidence with the common genes including; TLR4, TLR7, HLA-DRA, HLA-DQA1, CXCR4, FOS and TGFB2 (immune surveillance and chemokine pathways) and NF2, ITGA7, PGF, ITGA4, PDGFD and PARVA (focal adhesion). The gene discussed is TLR4; the disease is neoplasm.