Multivariable analysis showed MSM (OR, 5.18, 95%CI, 0.79–∞, p = 0.09) and CD4 count <100 cells/μL (OR, 9.55, 95%CI, 1.69–97.7, p<0.01) were the only independent clinical factors related to GI-KS. The gene discussed is CD4; the disease is Kaposi's sarcoma.