Upregulation of the EZH2 subunit of PRC2 (a complex with which CRNDE RNA has been shown to associate) has been reported in gliomas, especially glioblastomas, and appears necessary for maintenance of glioblastoma stem cell pluripotency and glioma cell proliferation (Suvà et al., 2009; Orzan et al., 2011). The gene discussed is EZH2; the disease is central nervous system cancer.