Defects in Gnas expression from the maternal allele can, therefore, disrupt various hormone signaling pathways, which leads to a range of disease symptoms termed “Pseudohypoparathyroidisms (PHP)” with or without “Albright’s Hereditary Osteodystrophy (AHO).” Typically, these comprise resistance to parathyroid hormone, thyroid stimulating hormone, growth hormone releasing hormone, gonadotrophins, and α-melanocyte stimulating hormone (Plagge et al., 2008; Chen et al., 2011; Mantovani, 2011). This evidence concerns the gene GNAS and pseudohypoparathyroidism type 1A.