Prominent examples are genome-wide association studies which led to the identification of novel breast cancer risk factors such as polymorphisms in FGFR2, CCND1, TOX3, MAP3K1, LSP1, CDKN2A, and 2B (Easton et al., 2007; Lambrechts et al., 2012). This evidence concerns the gene TOX3 and breast carcinoma.