It would be of particular interest to follow-up this finding in independent case control collection and functional studies to understand the observed effect of this variant, because other genetic polymorphisms with known functional consequence located in CYP3A4, CYP3A5, CYP3A7, and CYP3A43 showed no association with breast cancer risk (The MARIE-GENICA Consortium on Genetic Susceptibility for Menopausal Hormone Therapy Related Breast Cancer Risk, 2010). The gene discussed is CYP3A5; the disease is breast carcinoma.