KCND2 and myocardial infarction: Although it has been reported that expression of a constitutively active form of Cn increases Ito densities through the up-regulation of Kv4.2 transcript expression in neonatal rat ventricular myocytes (Gong et al., 2006), the transcriptional down-regulation of Kv4.2 across the ventricular wall (Rossow et al., 2006), as well as following myocardial infarction (Rossow et al., 2004), results from differences in [Ca2+]i that appear to underlie a differential activation of Cn and NFAT.