Both APP antibodies also detectedAPP epitopes in dystrophic neurites of senile plaques in ADAD (Fig. S3).Semiquantitative assessment of the neuritic component associated to amyloidplaques in parahippocampal and temporo-occipital cortices revealed that patientswith ADAD had a more prominent neuritic component than those with SAD(Fig. 4; Table 3) independently of the number of Aβ plaques. The gene discussed is APP; the disease is Senile plaques.