On the other hand, the induction of Pycard (also known as ASC, CARD5, TMS or TMS-1) has been alternatively reported by the same authors to be either dependent on p53 (after exposure to a genotoxic stress in the intrinsic mitochondrial pathway of apoptosis through a p53-Bax network) [29] or p53-independent (under hypoxic conditions in pancreatic cancer cells) (Figure 3) [30]. Here, TP53 is linked to familial pancreatic carcinoma.