There was no significant difference in Lp-PLA2 activity levels between the control group and the AD group (mean difference 1.7 nmol/min/ml, SD 6.8, P = 0.81) or aMCI group (mean difference 10.1 nmol/min/ml, SD 7.4, P = 0.17) in the unadjusted comparison. This evidence concerns the gene PLA2G7 and Alzheimer disease.