PLA2G7 and Alzheimer disease: Individuals aged ≥ 55 years old within the highest quartile of Lp-PLA2 activity had an increased risk of developing dementia over a mean follow-up of 5.7 years in the Rotterdam case-cohort study (HR 1.56; CI 1.03 to 2.37); the effect was greater on vascular dementia (HR 2.19, CI 0.80 to 6.03) than for the AD outcome (HR 1.30, CI 0.82 to 2.04) [5].