Additional objectives included: (i) exploring the associations between Lp-PLA2 and cerebrospinal fluid (CSF) markers of AD, (ii) assessing the association of Lp-PLA2 and markers of cardiovascular disease or diabetes in individuals with dementia, and (iii) investigating the relationship between Lp-PLA2 and APOE genotype. The gene discussed is APOE; the disease is Alzheimer disease.