STS can be classified into two main categories according to the type of genomic alteration: i) recurrent translocation driven STS, with reciprocal translocation resulting in oncogenic fusion transcripts (e.g. EWSR1-FLI1 in Ewing sarcoma, SS18-SSX in synovial sarcoma, PAX3-FOXO1 in alveolar rhabdomyosarcoma (aRMS), FUS-CHOP in myxoid/round-cell (MRC) liposarcoma), and[5] ii) STS with non-recurrent translocations (e.g. myxofibrosarcoma, leiomyosarcoma, liposarcoma [dedifferentiated liposarcoma and pleomorphic liposarcoma]). Here, EWSR1 is linked to telomere syndrome.