HIF1A and Familial prostate cancer: Recently, Iqbal et al. demonstrated that Mcl-1 expression is up-regulated by platelet derived growth factor (PDGF) in a HIF-1-dependent manner in prostate cancer cells and that pharmacological inhibition of the PDGF receptor decreases Mcl-1 levels and induces apoptosis in metastatic prostate cancer cells [37].