In a multivariate analysis, the following variables resulted statistically significant: total liver volume (p=0.001), tumor volume (p=0.002), total liver volume irradiated more than 30Gy (p=0.02), portal vein thrombosis (p=0.001), T stage (p=0.001), AJCC stage (p=001), BCLC stage (p<0.001) and baseline alpha fetoprotein level (p=0.02). This evidence concerns the gene AFP and neoplasm.