But his two episodes of arthropathy relapse shortly after discontinued penicillin treatment along with elevated inflammatory markers of CRP and ESR, as well as the fact that the arthropathy was healed with 7-year follow-up by repeated procedures of benzathine penicillin and 6-week methylprednisolone prompted us to consider the joint symptoms to be reactive rather than septic. The gene discussed is CRP; the disease is arthropathy.