While protection against C. neoformans strain H99γ required intact Th1-type cytokine responses, mice depleted of IL-17A and IL-17 receptor (R) A deficient (IL-17RA−/−) mice were able to survive acute infection with C. neoformans strain H99γ and no evidence of H99γ dissemination to the brain was observed[24]. This evidence concerns the gene IL17RA and infection.