Importantly, passive immunization through administration of anti-KLK6 antibodies or active immunization through administration of recombinant rat Klk6, to induce the production of anti-KLK6 antibodies, delayed significantly the onset and attenuated the symptoms of experimental autoimmune encephalomyelitis (EAE), the mouse model for multiple sclerosis[25]. The gene discussed is KLK6; the disease is experimental autoimmune encephalomyelitis.