Data demonstrating decreases in SVF cell numbers per gram of adipose tissue in ob/ob mice and decreases in percent of CD34+/Sca-1+/CD45- cells in SVF in ob/ob mice were opposite to our initial expectation that obesity induces hyperplasia of adipocytes as well as their precursor cells including SVF and CD34+/Sca-1+/CD45- cells. This evidence concerns the gene PTPRC and obesity due to melanocortin 4 receptor deficiency.