Table 2 summarizes the relationship between N-cadherin expression and the clinicopathological features of the breast cancers: membrane localization of N-cadherin in tumors significantly correlated with smaller tumor size (5 out of 36 cases pT1 vs. 1 out of 47 cases pT2, P = 0.04); in contrast, nuclear expression of N-cadherin was observed primarily in poorly differentiated tumors. This evidence concerns the gene CDH2 and neoplasm.