Therefore, when encountering steroid-resistant SLE-associated enteritis with the typical findings of CD, such as macroscopic findings of cobblestone-like inflammatory polyps, histopathological findings of noncaseating granuloma, and the presence of discontinuous longitudinal ulcers and aphthous ulcers in the colon, a diagnosis of CD should be considered in the differential, and anti-TNF-α therapy should be kept in mind. Here, TNF is linked to enteritis.