Recently, Fernandez-Funez et al. have described that the wild-type PrP can spontaneously convert into an insoluble protease-sensitive isoform in neurons of the transgenic fly brain expressing wild-type hamaster PrP, meanwhile, over-expression of Hsp70 is capable of preventing the accumulation of PrPSc-like conformers and reducing the neurotoxicity, which suggest that Hsp70 may be a therapeutic candidate for prion diseases [22]. Here, PRNP is linked to prion disease.