This polymorphism was assessed in conjunction with D vitamin in a prospective Chinese cohort of 217 cases and 890 controls.30 Although not significant, risk of colorectal cancer tended to be high among homozygous VDR variant genotypes with low intake of calcium in contrast to no change in risk by high intake of calcium (reference: homozygous wildtype genotype) (P-interaction 0.07). The gene discussed is VDR; the disease is colorectal cancer.