A prospective study found that carriers of the MGMT Ile143Val variant were at 43% higher risk of CRC by a daily intake of meat above 56 g per day compared with no increased risk by high meat intake among homozygous wildtype carriers (P-interaction 0.04).23 This result suggests that individuals with low DNA repair capacity of oxidative DNA damage are at a high risk of CRC by meat intake in contrast to individuals with the homozygous wildtype, whose risk seems to be unchanged by meat intake.23 The gene discussed is MGMT; the disease is colorectal carcinoma.