A significant interaction between genetic variation in ABCB1, but not ABCC2 or ABCG2, and meat intake in relation to CRC was found.6,18, Homozygous ABCB1 C3435T C-allele carriers were at 8% increased risk pr 25 g meat per day (95% CI: 1.00–1.16, P-interaction 0.02), whereas variant allele carriers were not at increased risk by meat intake. This evidence concerns the gene ABCC2 and colorectal carcinoma.