IL10 and colorectal carcinoma: The protective effect of dietary fibre on risk of CRC is well documented.28 Fibre is the indigestible portion of plant foods whereof the insoluble fibre has bulking action and the soluble fibre is fermented by colonic bacteria to short chain fatty acid, including butyrate, which has anti-inflammatory properties.29 IL-10 is an anti-inflammatory cytokine and IL10−/− mice develop intestinal inflammation.