The kinetics of VDR accumulation in AML cells is surprisingly fast after exposure of the cells to 1,25(OH)2D. In HL60 cells, VDR starts to accumulate in the cell nuclei after few minutes from exposure to 1,25(OH)2D [42] and after half of an hour the difference is significant (Figure 5(a)). This evidence concerns the gene VDR and acute myeloid leukemia.