A murine model of the human 5q-syndrome was developed in which haploinsufficiency of the Cd74-Nid67 (CD74 antigen gene—nerve growth factor-induced differentiation clone 67 gene) region containing the RPS14 gene on mouse chromosome 18 maps CDR of the human 5q-syndrome and contains 8 known genes [49]. This evidence concerns the gene SMIM3 and myelodysplastic syndrome associated with isolated del(5q).