Paying attention to genes characteristic to MCD, a naïve B-cell marker: surface Ig lambda (XM_066332), B-cell specific markers: PAX 5 (NM_016734), Oct2 (XM_068123), and a GC B-cell marker: BCL6 (NM_001706) were higher in BL cell lines and preplasma cell markers; IRF4/MUM1 (NM_002460) and PRDM1/BLIMP1 (NM_001198) are definitely higher in PEL cells, assuring that BL should be derived from GC B cell and PEL from post-GC plasmablasts (Figure 2, Table 2). This evidence concerns the gene IRF4 and Burkitt lymphoma.