Troglitazone inhibited the constitutive expression of GSK-3β and activation of NFκB. Cotreatment of troglitazone with a GSK-3β inhibitor (AR-a014418) or GSK-3β siRNA significantly augmented the inhibitory effect of troglitazone on the NFκB activity and on prostate cancer cell growth inhibition and apoptotic cell death. This evidence concerns the gene GSK3B and Familial prostate cancer.