PPARG and inflammatory bowel disease: An interesting message appears in “PPARγ in inflammatory bowel disease” by V. Annese et al. After describing the potential of PPARγ in inflammatory-induced mechanisms, the authors reflected on the link between microbiota and PPARγ receptor, considering it worth further studies, since some commensal bacterial or natural ligands of foods may directly activate and increase the expression of PPARγ, thus determining a “biologic” anti-inflammatory action.