PPARA and metabolic dysfunction-associated steatohepatitis: In nonalcoholic steatohepatitis (NASH) and simple steatosis, besides reducing steatosis by regulation lipid and lipoprotein metabolism, treatment of mice with the PPARα activator Wy14643 protects steatotic livers against IR injury, with the benefits of this treatment potentially occuring through dampening vascular cellular adhesion molecule-1 and cytokine responses and activation of NF-κB and IL-6 production [84].