NFKB1 and ischemia reperfusion injury: The former contradictory results have suggested that the role of NF-κB activation during hepatic ischemia-reperfusion injury is controversial because it induces both protective and proinflammatory genes [85] and NF-κB inactivation either protects against hepatic IR injury [86–88] or aggravates such injury [45, 89, 90].