According to the PANTHER Classification System, in vitro berberine targets correlate with a mixture of biological pathways, such as Alzheimer disease-presenilin and secretase pathways, angiogenesis, apoptosis signalling pathway, FAS signalling pathway, Huntington disease, inflammation mediated by chemokine and cytokine signalling pathways, interleukin signalling pathway, and p53 pathways (Table 5). This evidence concerns the gene TP53 and juvenile Huntington disease.