INS and early-onset autosomal dominant Alzheimer disease: Regarding the GHRH-GH-IGF axis, MIA-690 decreased the secretion of IGF-I (Fig. 6) in the supernatant of HCN-2 cell cultures which is critical since in Alzheimer's disease one of the most important pathologic phenomena, is the competition of insulin and amyloid-β for insulin-degrading enzyme (IDE).