GPX1 and early-onset autosomal dominant Alzheimer disease: Since oxidative stress and inflammation are key pathologic processes in Alzheimer's disease [1], direct assessment of reactive oxygen species formation was also performed by aminophenyl-fluorescein (APF) assays, while the expression of superoxide dismutase 1 (SOD1) and glutathione-peroxidase 1 (GPx1) was determined by ELISA.