SLC25A27 and Parkinson disease: It is interesting to note that mice with knock out of DJ-1 (mutations of which has been associated with an autosomal recessive young onset form of PD) had reduced UCP4 and 5 expression specific to the substantia nigra pars compacta, sparing the cortex, hippocampus and the ventral tegmental area, indicating that these neuronal UCPs may play a role in calcium-induced uncoupling specifically in SNc DA neurons [60].