APOE and Obesity: Negative associated factors included Live alone (*Pearson’s P value = 0.004; Fisher’s P value = 0.007), more number of children(≥3) (*Pearson’s P value < 0.001; Fisher’s P value < 0.001), Aging (* Pearson’s P value <0.001), Diabete (OR = 1.42, Pearson’s P value = 0.007; Fisher’s P value = 0.009), Obesity (BMI ≥30) (OR = 1.63, Pearson’s P value=0.048; Fisher’s P value =0.06), Dysuria (OR =1.59 for chronic dysuria), Constipation (OR=1.40 for constipation, Pearson’s P value = 0.006; Fisher’s P value = 0.008), and ApoE homozygous (OR=3.00, Pearson’s P value = 0.007).