To date, the potential beneficial effect of neurotrophins, NGF and BDNF, in particular, have been explored in light of several neurodegenerative disorders, including but not limited to AD, Amyotrophic lateral sclerosis (ALS) [29], Huntington disease [30], Parkinson’s Disease and even obesity [31] (Table 1). This evidence concerns the gene BDNF and obesity due to melanocortin 4 receptor deficiency.