APC and malignant colon neoplasm: The Fzd7 protein is abundantly expressed in colon cancer tissues and various colon cancer cell lines that also contain mutated APC or CTNNB1. Herbergs et al. [44] examined the mRNA levels of Fzd7 in 135 primary colorectal cancers by real-time PCR and found that the Fzd7 mRNA levels were significantly higher in stage II, III, or IV tumors than in nontumor tissues and that overall survival was shorter in those patients with higher Fzd7 expression.