Examples of genes containing coding repeats that are targets for mutation in CRC with MSI include genes related with DNA repair (RAD50, MSH2, MSH3, MSH6, MLH1, BLM, PMS2), apoptosis (APAF1, BAX, BCL10, Caspase-5), signal transduction (TGFβRII, ACTRII, IGFIIR, WISP-3), cell cycle (PTEN, RIZ), and transcription factors (TCF-4) [58]. This evidence concerns the gene PMS2 and colorectal carcinoma.