BAX and colorectal carcinoma: Examples of genes containing coding repeats that are targets for mutation in CRC with MSI include genes related with DNA repair (RAD50, MSH2, MSH3, MSH6, MLH1, BLM, PMS2), apoptosis (APAF1, BAX, BCL10, Caspase-5), signal transduction (TGFβRII, ACTRII, IGFIIR, WISP-3), cell cycle (PTEN, RIZ), and transcription factors (TCF-4) [58].