Recently, the ORIGIN trial showed that, in comparison with a standard oral therapy based on metformin and sulfonylureas, basal insulin did not produce any beneficial effect neither on cardiovascular diseases, nor on microvascular diabetic complications, while increasing the risk of hypoglycemia and weight gain [59]; based on these results, an early use of insulin in patients with type 2 diabetes is not justified when a fair metabolic control can be reached with other drugs. Here, INS is linked to Hypoglycemia.