The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) study compared, in patients with acute coronary syndromes, the effect of prolonged insulin-providing (i.e., insulin and/or sulfonylureas) and insulin-sensitizing (i.e., metformin and/or thiazolidinediones) glucose-lowering therapy; the number of cancer-related deaths was similar in the two treatment groups (72 versus 70), whereas no information was provided on the incidence of malignancies [61]. Here, INS is linked to acute coronary syndrome.