By crosslinking tyrosinase to hemoglobin to form polyhemoglobin-tyrosinase, we can simultaneously act on tyrosine and increase oxygenation for melanoma cells to be more sensitive to the lowered tyrosine level or the toxic effects of tyrosine metabolites, resulting in the inhibition of murine B16F10 melanoma growth in mice [44, 45]. Here, TYR is linked to melanoma.