Several chemokines related to the inflammatory process of RA are ligands of DARC, such as the CXC type chemokine, the interleukin-8 (IL-8) and neutrophil-activating protein derived from epithelial cells (ENA-78: epithelial cell-derived neutrophil-activating protein-78), and the CC type, such as chemoattractant protein of monocyte (MCP-1 monocyte chemoattractant protein-1) and the regulated protein of T lymphocytes expressed and secreted in normal activation (RANTES: regulated on activation normal T-cell expressed and secreted). The gene discussed is ACKR1; the disease is rheumatoid arthritis.