CD4 and asthma: In a murine model of ovalbumin-induced asthma, inhibition of lung inflammatory process, by S. mansoni eggs or by the S. mansoni antigens, Sm22.6, PIII, and rSm29 were associated with an increase in the number of CD4+CD25+Foxp3+ T cells and high levels of IL-10 production [49, 50].